The gala honoring excellence in music is to air live from the Staples Center on CBS on Jan. 26.
Lizzo leads the field with eight nominations, followed by Billie Eilish and Lil Nas X with six nominations each.
Alicia Keys is hosting the event for the second year in a row.
Grande wrapped up her Sweetener concert tour and released her first live album in December.
She is nominated for five Grammys, including Album of the Year for Thank U, Next, which includes the hit singles “Thank U, Next,” “7 Rings” and “Break Up with Your Girlfriend, I’m Bored.”
Reporting by Karen Butler
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